Natural Product Synthesis
Our aim is to study and develop new organic transformations. The main motivation is applying those new methodologies in the total synthesis of bioactive compounds.
Current Targets
Anachelin H
Anachelin H is a complex metabolite isolated from Anabaena cylindrica, it was suggested that Anachelin acts as a siderophore. Which are small molecules liberated by bacteria to complex iron in a close environment. Our interest is the synthesis of Anachelin-Antibiotic conjugates and the study of these molecules as antibacterial agents.
Published Results:
Bengazol A
Different bengazoles have been isolated and its principal difference is the R group on the secondary oxygen. These compounds are isolated from marine organisms (sponges) and they have shown potent antifungal activity. Typically bengazole A is know to have a potent activity against Candida Albicans comparable to amphotericin B.
Published Results:
Eur. J. Org. Chem., 2018, 48, 6929; Org. Biomol. Chem., 2018,16, 1277; Org. Biomol. Chem., 2017, 15, 301
5Z-7-oxozeaenol
Resorcylic acid lactones (RALs) are compounds capable of selective inhibition of TAK1 protein. We are interested in the synthesis of 5Z-7-oxozeaenol using biocatalytic reductions to install the stereogenic centers.
Completed Targets
Izidine Alkaloids
We completed the synthesis of four natural alkaloids, plus the valmerins core using an aldol-type cyclization of activated imides.
See the synthesis in: