Anachelin H is a complex metabolite isolated from Anabaena cylindrica, it was suggested that Anachelin acts as a siderophore. Which are small molecules liberated by bacteria to complex iron in a close environment. Our interest is the synthesis of Anachelin-Antibiotic conjugates and the study of these molecules as antibacterial agents.
Published Results:
Different bengazoles have been isolated and its principal difference is the R group on the secondary oxygen. These compounds are isolated from marine organisms (sponges) and they have shown potent antifungal activity. Typically bengazole A is know to have a potent activity against Candida Albicans comparable to amphotericin B.
Published Results:
Eur. J. Org. Chem., 2018, 48, 6929; Org. Biomol. Chem., 2018,16, 1277; Org. Biomol. Chem., 2017, 15, 301
Resorcylic acid lactones (RALs) are compounds capable of selective inhibition of TAK1 protein. We are interested in the synthesis of 5Z-7-oxozeaenol using biocatalytic reductions to install the stereogenic centers.
We completed the synthesis of four natural alkaloids, plus the valmerins core using an aldol-type cyclization of activated imides.
See the synthesis in: