The use of twisted amides to increase the electrophilic character of the C=O(N) bond has been studied by several research groups. Subsequent reactions of the amide bond, including transamidation produce significant amounts of residues. Our research focuses on the development of atom economic processes of transamidation of activated secondary amides.

Amines, produced by a transamidation exchange, are usually discarded, or seen as residues. Our team works in the connection of transamidation reaction and cross-coupling reactions to synthesize complex primary amines.

A transamidation reaction of thioacetamide with primary and secondary amines was described. The use of catalytic amounts of SbCl₃ notably increases the yields and diminishes the reaction times.

Tetrahedron Lett., 2015, 56, 4308.

A highly improved and green methodology for the direct amidation of carboxylic acids with amines using silica gel as a solid support and catalyst was described. The scope of this method is exemplified using several aliphatic, aromatic, unsaturated and fatty acids. The reaction is also applied to different primary and secondary amines.

Green Chem., 2015,17, 3157.